منابع مشابه
Eosinophilic bioactivities in severe asthma
Asthma is clearly related to airway or blood eosinophilia, and asthmatics with significant eosinophilia are at higher risk for more severe disease. Eosinophils actively contribute to innate and adaptive immune responses and inflammatory cascades through the production and release of diverse chemokines, cytokines, lipid mediators and other growth factors. Eosinophils may persist in the blood and...
متن کاملMepolizumab (Nucala) For Severe Eosinophilic Asthma.
Mepolizumab (Nucala) for severe eosinophilic asthma.
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Affiliations: Dept of Pulmonary Medicine, Mainz University Hospital, Mainz, Germany. Dept of Respiratory Medicine, Université Paris-Sud, Paris, France. Dept of Respiratory Medicine and Allergology, Skåne University Hospital, Lund, Sweden. Dept of Respiratory Medicine, Aix-Marseille University, Marseille, France. Dept of Respiratory Medicine, Queen’s University Belfast, Belfast, UK. Nuffield Dep...
متن کاملBiomarkers and severe asthma: a critical appraisal
Severe asthma (SA) is a clinically and etiologically heterogeneous respiratory disease which affects among 5-10 % of asthmatic patients. Despite high-dose therapy, a large patients percentage is not fully controlled and has a poor quality of life. In this review, we describe the biomarkers actually known in scientific literature and used in clinical practice for SA assessment and management: ne...
متن کاملClinical usefulness of mepolizumab in severe eosinophilic asthma
Asthma is a chronic inflammatory disorder of the airways with variable clinical severity from very mild and occasional symptoms to recurrent critical exacerbations, at risk of fatal or near-fatal outcome, in a small percentage of patients. Within the different inflammatory cascades involved in asthma, eosinophils play a central role in the pathogenesis and largely influence disease severity. In...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2017
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2017.10.005